Focal Lesions Are Important Contributors To The Progression Of Myelnoma

LITTLE ROCK — Researchers with the Myeloma Institute at the University of Arkansas for Medical Sciences (UAMS) have connected clinical outcomes for patients with types of so-called focal lesions, which are solid, elevated areas of plasma cell accumulations within the bone present in most myeloma patients.

The focal lesions are important contributors to the progression of the disease and are found through radiology imaging techniques.

The team headed by Leo Rasche, M.D., Faith Davies, M.D., and Niels Weinhold, Ph.D., show for the first time the prognostic value of focal lesion size in myeloma. They reported these findings May 21 in the online edition of Blood, Journal of the American Society of Hematology in the article “The Presence of Large Focal Lesions is a Strong Independent Prognostic Factor in Multiple Myeloma.”

Last year, the institute’s researchers discovered cancer cells can vary depending on their location, with the most aggressive tumors frequently only found in focal lesions.    MORE

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